免疫系统
癌症
癌症研究
生物
癌细胞
免疫学
免疫
医学
遗传学
作者
Yankuo Liu,Zhiyuan Shi,Zeyuan Zheng,Jinxin Li,Kunao Yang,Chunlan Xu,Qing Liu,Zhicheng Gong,Yi Yang,Yue Zhao,Zuodong Xuan,Huimin Sun,Chen Shao
标识
DOI:10.3390/ijms231911590
摘要
Although STK38 (serine-threonine kinase 38) has been proven to play an important role in cancer initiation and progression based on a series of cell and animal experiments, no systemic assessment of STK38 across human cancers is available. We firstly performed a pan-cancer analysis of STK38 in this study. The expression level of STK38 was significantly different between tumor and normal tissues in 15 types of cancers. Meanwhile, a prognosis analysis showed that a distinct relationship existed between STK38 expression and the clinical prognosis of cancer patients. Furthermore, the expression of STK38 was related to the infiltration of immune cells, such as NK cells, memory CD4+ T cells, mast cells and cancer-associated fibroblasts in a few cancers. There were three immune-associated signaling pathways involved in KEGG analysis of STK38. In general, STK38 shows a significant prognostic value in different cancers and is closely associated with cancer immunity.
科研通智能强力驱动
Strongly Powered by AbleSci AI