Enantioselective Deoxygenative Amino-Cyanation of Carboxylic Acids via Ti-Multicatalysis

Carboxylic acids are valued synthetic building blocks that offer shelf life stability, structural diversity, and wide commercial availability. Despite the remarkable synthetic utility of carboxylic acids, a direct enantioselective deoxygenative functionalization of carboxylic acids remains rare. We present enantioselective deoxygenative amino-cyanation of carboxylic acids using a novel TiIV-multicatalytic system that catalytically modified each C–O bond of carboxylic acid to C–C, C–N, and C–H bonds, generating enantio-enriched chiral α-amino nitriles (up to 98:2 er).