细胞内
谷胱甘肽
化学
谷氨酰胺
癌细胞
聚吡咯
免疫系统
生物物理学
纳米技术
癌症研究
生物化学
癌症
材料科学
酶
生物
免疫学
医学
聚合
内科学
有机化学
氨基酸
聚合物
作者
Ni Zhang,Ping Wei,Koya Prabhakara Rao,Zhenlin Zhang,Rong Huang,Daoming Zhu,Guoxin Li,Shipeng Ning
标识
DOI:10.1016/j.jconrel.2024.05.045
摘要
Cuproptosis, a newly discovered mechanism of inducing tumor cell death, primarily relies on the intracellular accumulation of copper ions. The utilization of Cu-based nanomaterials to induce cuproptosis holds promising prospects in future biomedical applications. However, the presence of high levels of glutathione (GSH) within tumor cells hinders the efficacy of cuproptosis. In this study, we have developed a BPTES-loaded biomimetic Cu-doped polypyrrole nanoparticles (CuP) nanosystem (PCB) for enhanced cuproptosis and immune modulation. PCB comprises an internal BPTES and CuP core and an external platelet membrane (PM) that facilitates active targeting to tumor sites following intravenous administration. Subsequently, PCB effectively suppresses glutaminase (GLS1) activity, thereby reducing GSH content. Moreover, CuP catalyze intracellular H
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