硅氢加成
对映选择合成
化学
功能群
催化作用
基质(水族馆)
镍
立体选择性
组合化学
立体化学
有机化学
海洋学
地质学
聚合物
作者
Tao Liu,Xin‐Rui Mao,Shuo Song,Zi‐Yang Chen,Yichen Wu,Li‐Ping Xu,Peng Wang
标识
DOI:10.1002/anie.202216878
摘要
Here, we report the first example of Ni-catalyzed asymmetric hydrosilylation of 1,1-disubstituted allenes with high level of regioselectivities and enantioselectivities. The key to achieve this stereoselective hydrosilylation reaction was the development of the SPSiOL-derived bisphosphite ligands (SPSiPO). This protocol features broad substrate scope, excellent functional group, and heterocycle tolerance, thus provides a versatile method for the construction of enantioenriched tertiary allylsilanes in a straightforward and atom-economic manner. DFT calculations were performed to reveal the reaction mechanism and the origins of the enantioselectivity.
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