脂质双层融合
生物
细胞融合
细胞生物学
细胞质
细胞外
细胞膜
膜蛋白
病毒进入
细胞
融合蛋白
膜
病毒
病毒学
基因
生物化学
病毒复制
重组DNA
出处
期刊:Virology
[Elsevier]
日期:2006-01-01
卷期号:344 (1): 48-54
被引量:267
标识
DOI:10.1016/j.virol.2005.09.037
摘要
The study of poxvirus entry and membrane fusion has been invigorated by new biochemical and microscopic findings that lead to the following conclusions: (1) the surface of the mature virion (MV), whether isolated from an infected cell or by disruption of the membrane wrapper of an extracellular virion, is comprised of a single lipid membrane embedded with non-glycosylated viral proteins; (2) the MV membrane fuses with the cell membrane, allowing the core to enter the cytoplasm and initiate gene expression; (3) fusion is mediated by a newly recognized group of viral protein components of the MV membrane, which are conserved in all members of the poxvirus family; (4) the latter MV entry/fusion proteins are required for cell to cell spread necessitating the disruption of the membrane wrapper of extracellular virions prior to fusion; and furthermore (5) the same group of MV entry/fusion proteins are required for virus-induced cell-cell fusion. Future research priorities include delineation of the roles of individual entry/fusion proteins and identification of cell receptors.
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