经络
氧化应激
过氧化氢酶
谷胱甘肽
活性氧
抗氧化剂
化学
谷胱甘肽过氧化物酶
真皮成纤维细胞
生物化学
药理学
细胞生物学
成纤维细胞
类黄酮
生物
酶
体外
柚皮素
作者
Visarut Buranasudja,Chawanphat Muangnoi,Kittipong Sanookpan,Hasseri Halim,Boonchoo Sritularak,Pornchai Rojsitthisak
出处
期刊:Nutrients
[MDPI AG]
日期:2022-06-20
卷期号:14 (12): 2553-2553
被引量:21
摘要
Oxidative stress in dermal fibroblasts is strongly correlated with the aging process of the skin. The application of natural compounds that can increase the ability of dermal fibroblasts to counteract oxidative stress is a promising approach to promote skin health and beauty. Eriodictyol is a flavonoid that exerts several pharmacological actions through its antioxidant properties. However, its protective effects on dermal fibroblasts have not yet been investigated. In this study, we investigated whether eriodictyol protects human dermal fibroblasts (BJ fibroblasts) from the harmful effects of hydrogen peroxide (H2O2). Eriodictyol pretreatment significantly prevented necrotic cell death caused by H2O2 exposure. In addition, the level of 2',7'-dichloro-dihydro-fluorescein oxidation was decreased, and that of glutathione was maintained, indicating that the beneficial effects of eriodictyol against H2O2 were closely associated with oxidative-stress attenuation. Eriodictyol mediates its antioxidant effects on dermal fibroblasts against H2O2 through (i) the direct neutralization of reactive oxygen species; (ii) the enhancement of the activities of H2O2-detoxifying enzymes, including catalase and glutathione peroxidase; and (iii) the induction of the expressions of catalase and glutathione peroxidase 1 via the activation of the Nrf2 signaling system. These results support the potential application of eriodictyol as an ingredient in skincare products for cosmeceutical and pharmaceutical purposes.
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